ChloroquineV1, Main, Exploration, bibRecord, 003699

Kinetics of the distribution and elimination of chloroquine in the rat

Identifieur interne : 003699 ( Main/Exploration ); précédent : 003698; suivant : 003700

Kinetics of the distribution and elimination of chloroquine in the rat

Auteurs : S. A. Adelusi [Nigeria] ; L. A. Salako [Nigeria]

Source :

General Pharmacology [ 0306-3623 ] ; 1982.

RBID : ISTEX:6409752002E2AE701AA99FB6DB8A6AE3F83335F8

English descriptors

Teeft :
- Antibiotics chemother, Antimalarial activity, Biological samples, Blood cell, Blood cells, Chloroquine, Chloroquine concentration, Concentration time curve, Concentration time curves, Different rates, Different tissues, Dos, Elimination curve, Elimination rate, Ether, Ether extracts, Exponential functions, Kinetics, Laboratory studies, Maximum concentration, Maximum fluorescence, Mcchesney, Observation period, Other tissues, Peak concentration, Pergamon press, Pharmacokinetic parameters, Phosphate borate buffer, Plasma, Plasma concentration ratio, Rapid phase, Rate constants, Sampling duration, Sampling period, Single dose, Slow phase, Tissue concentrations, Tissue homogenate, True terminal slope, Various tissues, Weekly doses.

Abstract

Abstract: 1. 1. The distribution of chloroquine was studied in the tissues and blood of rat. 2. 2. The time to peak concentration and the maximum concentration varied in various tissues and were higher than for plasma and red blood cells. 3. 3. The tissue to plasma concentration ratio increased with time up to 144th hr for some tissues while this ratio was still increasing at the 168th hr for other tissues. 4. 4. The values of β estimated for the tissues were lower than those for plasma or red blood cells. The values differed from one another for the tissues but were similar for plasma and red blood cells.

Url:

https://api.istex.fr/ark:/67375/6H6-53X55BCT-G/fulltext.pdf

DOI: 10.1016/0306-3623(82)90110-0

Affiliations:

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Le document en format XML

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<term>Chloroquine</term>
<term>Chloroquine concentration</term>
<term>Concentration time curve</term>
<term>Concentration time curves</term>
<term>Different rates</term>
<term>Different tissues</term>
<term>Dos</term>
<term>Elimination curve</term>
<term>Elimination rate</term>
<term>Ether</term>
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<term>Kinetics</term>
<term>Laboratory studies</term>
<term>Maximum concentration</term>
<term>Maximum fluorescence</term>
<term>Mcchesney</term>
<term>Observation period</term>
<term>Other tissues</term>
<term>Peak concentration</term>
<term>Pergamon press</term>
<term>Pharmacokinetic parameters</term>
<term>Phosphate borate buffer</term>
<term>Plasma</term>
<term>Plasma concentration ratio</term>
<term>Rapid phase</term>
<term>Rate constants</term>
<term>Sampling duration</term>
<term>Sampling period</term>
<term>Single dose</term>
<term>Slow phase</term>
<term>Tissue concentrations</term>
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<front><div type="abstract" xml:lang="en">Abstract: 1. 1. The distribution of chloroquine was studied in the tissues and blood of rat. 2. 2. The time to peak concentration and the maximum concentration varied in various tissues and were higher than for plasma and red blood cells. 3. 3. The tissue to plasma concentration ratio increased with time up to 144th hr for some tissues while this ratio was still increasing at the 168th hr for other tissues. 4. 4. The values of β estimated for the tissues were lower than those for plasma or red blood cells. The values differed from one another for the tissues but were similar for plasma and red blood cells.</div>
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Kinetics of the distribution and elimination of chloroquine in the rat

Kinetics of the distribution and elimination of chloroquine in the rat

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri